Endocrine Abstracts

Melatonin inhibits vascular smooth muscle cell proliferation and apoptosis through upregulation of Sestrin2Excessive vascular smooth muscle cell (VSMC) proliferation contributes to the development of atherosclerosis and restenosis. On the other hand, apoptosis of VSMCs accelerates plaque rupture in the atherosclerotic vessels. Therefore, a strategy that regulates both VSMC proliferation and apoptosis is essential for the development of new pharmacologica...

Background: Pregnancy with Cushing syndrome (CS) is rare because infertility is associated with hypogonadotrophic hypogonadism by cortisol and androgens excess. Here we reported the cases of CS that presented signs and symptoms of CS after delivery.Case reports: The first case is a 30-year-old woman who presented 8 months after second baby delivery amenorrhea even though she stopped breastfeeding. For 3 months before her visit, she gained weight and had ...

Background: Recently, diabetic mortality is lower than ever before, likely due to dramatic improvements in diabetes care. This study set to analyze changes in the cause of death in type 2 diabetes mellitus (T2DM) in the past 20 years.Methods: All subjects were T2DM patients over the age of 30 whose death certificates were issued at six hospitals in the Busan metropolitan area from 2010 to 2014. The patients were excluded if they had been clinically diagn...

Objective: Hypoglycemia is a common adverse event and one of the main obstacles to achieving good glycemic control to minimize the risk of diabetic complications in patients with diabetes. Therefore, most physicians try to reduce hypoglycemia events through education about hypoglycaemia, such as diabetes self-management education. In this study, we surveyed the actual insight about hypoglycemia, behavior of diabetic patients to avoid hypoglycemia and the fear of hypoglycemia.<...

The objectives of this study were to investigate intertemporal choice in patients with type 2 Diabetes and whether blood glucose control is related to intertemporal choice. Ninety seven diabetes patients (41 inpatients and 56 outpatients) were recruited. All patients were subjected to the following tests: DM Distress Scale (DDS), Beck Anxiety Inventory (BAI), the Center for Epidemiologic Studies Depression Scale (CES-D) and the Big Five Inventory-K-10 (BFI-K-10). 73 of recruit...

Pancreatic beta cell senescence is one of the recent explanations for theincreased prevalence of type 2 diabetes in the elderly. Aging may exert a distinct influence on pancreatic β cell turnover, regeneration capacity and function. Oxidative stresses induced by metabolic stresses reduce pancreatic beta cell mass and secretion. We investigated how metabolic stresses effect on pancreatic beta cell senescence. INS-1 cells were exposed to 33mM glucose (glucotoxicity: high gl...

Beta cell senescence is being regarded as the one of the mechanisms of beta cell dysfunction. Melatonin secreted primarily from the pineal glandregulates a variety of physiological functions, such as sleep, circadian rhythms, and neuroendocrine actions. Melatonin has also very strong anti-oxidant effects. The effects of melatonin on the pancreatic beta cell senescence induced by glucolipotoxicity have not been studied. INS-1 cells were exposed to 33mM glucose with palmitate 20...

Abstract withdrawn....

Aims: High level of uric acid is known to associate with stroke, coronary artery disease and metabolic syndrome. Some epidemiologic studies suggested that high uric acid level is connected with dyslipidemia. However, this relationship was not examined in type 2 diabetic patients. This study was conducted to investigate the association between serum uric acid level and lipid profiles in type 2 diabetic patients.Methods: A total of 972 type 2 diabetes pati...

Abstract withdrawn....